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KMID : 0624620190520040283
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BMB Reports
2019 Volume.52 No. 4 p.283 ~ p.288
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Interleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
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Hong Sung-Wook
O Eun-Ju
Lee Jun-Young
Yi Jae-U
Cho Kyung-Jin
Kim Ju-Hee
Kim Da-Eun
Surh Charles D.
Kim Kwang-Soon
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Abstract
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Foxp3＋ regulatory CD4＋ T (Treg) cells play an essential role in preventing overt immune responses against self and innocuous foreign antigens. Selective expansion of endogenous Treg cells in response to the administration of interleukin (IL)-2/antibody complex, such as the IL-2/JES6-1 complex (IL-2C) in mice, is considered an attractive therapeutic approach to various immune disorders. Here, we investigated the therapeutic potential of IL-2C in allergic airway inflammation models. IL-2C treatment ameliorated Th17-mediated airway inflammation; however, unexpectedly, IL-2C treatment exacerbated Th2-mediated allergic airway inflammation by inducing the selective expansion of Th2 cells and type-2 innate lymphoid cells. We also found that IL-2 signaling is required for the expansion of Th2 cells in lymphoproliferative disease caused by Treg cell depletion. Our data suggest that IL-2C is selectively applicable to the treatment of allergic airway diseases depending on the characteristics of airway inflammation.
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KEYWORD
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Airway inflammation, Foxp3＋ regulatory T cell, IL-2/antibody complex, Th17, Th2
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